Ranger® Technology
Yourgene Health uses Ranger® Technology in our DNA size selection instruments to deliver dynamic target enrichment of DNA.
Core automated size selection functionality is complemented by the ability to perform fragment length analysis and fluorescence assays for Next-Generation Sequencing (NGS) quality control applications.
Ranger® Technology has so far been deployed to power multiple solutions across our instrumentation portfolio, with applications from oncology, gene synthesis, Non-Invasive Prenatal Testing (NIPT) and beyond.
Ranger® Technology offers a fast, effective and efficient automated solution for separating DNA molecules based on their size and electrical charge; it uses a patent-protected, machine-vision algorithms to interpret the gel electrophoresis process in real time.
| Ranger® Technology |
LighBench®
|
LightBench® Discover
|
NIMBUS® Select
High-Throughput Platform
|
|---|---|---|---|
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| Application: NIPT | |||
| Application: Gene Synthesis | |||
| Application: Long-Read Sequencing | |||
| Functionality: Size Selection | |||
| Functionality: Fragment Length Analysis | |||
| Functionality: Fluorometric Assay | |||
| Throughput: samples per run | 12 | 12 | 96 |
Combined with our dual reference size markers, which can be selected in line with the target of interest, ensures Ranger® Technology achieves a repeatable, high precision of 97%. In terms of recovery, we have high intrinsic recovery and resulting yields, which can result in higher enrichment of the DNA fragments of interest, and also achieve reduced noise in subsequent sequencing data.
The high precision imaging feeds data into the algorithms which cleverly interpret the DNA separation process. The voltage is modulated per channel to control migration of DNA which ensures recovery yields are consistently over 70%. Extraction volumes can be kept to under 35 µL volumes to ensure a high concentration of DNA for downstream processing.
As well as size selection, Ranger® Technology also offers the ability to perform fragment length analysis and sample quantification with fluorescence-based assays. This results in time and reagent savings, allowing for accurate DNA quantification that can be integrated with automated workflows, giving better quality control of your samples.
To complement our instruments, we have developed a range of consumables and reagents which have been optimised for use on these platforms. Please contact us to find out more.
Ranger® Technology offers industry-leading scalability and precision for the size selection process, ensuring maximal enrichment, every time. Providing clinical and research laboratories with true walk away time, reducing workflow costs and improving yields.
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