Pregnancy Loss Testing and Trisomy Detection
Chromosomal abnormalities are a leading cause of recurrent miscarriage, responsible for up to 50% of first-trimester losses, with autosomal trisomies accounting for around 60% of these cases.
Products of conception analysis after recurrent pregnancy loss provides rapid, actionable insights, helping clinicians guide families with informed counselling and future reproductive planning.
Designed to provide clarity
The Yourgene® QST*R Pregnancy Loss assay is designed for the in vitro quantitative detection of the six most common autosomal trisomies associated with pregnancy loss.
Using Quantitative Fluorescent Polymerase Chain Reaction (QF-PCR) technology, this assay is designed to amplify highly polymorphic short tandem repeat (STR) regions on the chromosomes of interest.
Yourgene QST*R Pregnancy Loss assay detects:
- Trisomy 13 (Patau syndrome)
- Trisomy 15
- Trisomy 16
- Trisomy 18 (Edwards syndrome)
- Trisomy 21 (Down syndrome)
- Trisomy 22
Offering insight and direction
Additional markers for the X and Y chromosomes and the TAF9L marker allow assessment of the fetal sex chromosome abnormalities, supporting comprehensive aneuploidy analysis.
Rapid Workflow. Faster Patient Results.
The Yourgene® QST*R Pregnancy Loss assay is compatible with most commonly employed DNA extraction protocols, thermal cyclers and capillary electrophoresis instruments.
This flexibility in approach is complemented by simple and easy to use analysis software for reporting. Results can be analysed through either Life Technologies GeneMapper™ or SoftGenetics GeneMarker® software.
GeneMarker’s® operation now includes a customised Trisomy Analysis function. By selecting BPG (Best Practice Guidelines) settings within the Trisomy Analysis function users can quickly and accurately measure allele ratios to obtain a full patient sample report within minutes.
Test Features
- Simple set up – one tube per sample
- Rapid – minimum hands on time, just add DNA
- One step protocol – DNA extraction to PCR
- Reduced risk of sample mix-up
- Efficient – fewer consumables, reduced cost
- Validated for use on the ABI 3130 and 3500 Genetic Analyzers
- Highly informative – multiplexed 5 dye chemistry
- No post-PCR manipulation
- One capillary per sample
- Cost effective – less instrument consumables
- GeneMarker™ and GeneMapper® software applications
- Simple data review and analysis
- Easy to use intuitive software
- Informative single page report
- No data transfer required
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