Male Factor Infertility (MFI)
Infertility affects 10–15% of couples, with male factors contributing to around 50% of these cases. While many causes remain unknown, genetic abnormalities are a key contributor to impaired sperm production including oligospermia or azoospermia.
Sex chromosome aneuploidies and Y-chromosome microdeletions are among the most common genetic causes of male infertility. Male Factor Infertility analysis provides a targeted screening approach to detect these genetic causes and enable early diagnosis and intervention.
Providing insight into genetic causes of infertility, helps couples optimise their chances of conceiving with assisted reproductive technology (ART) and fertility treatment.
Designed to provide clarity
The Yourgene® Male Factor Infertility range provides fast, accurate detection of key genetic causes of male infertility using a carefully selected panel of markers.
Designed for clarity and confidence, the single-tube assay employs Quantitative Fluorescent Polymerase Chain Reaction (QF-PCR), where fluorescent dye-labelled primers amplify key regions of the sex chromosomes.
DNA for analysis is obtained from whole blood samples, enabling detection of:
- Sex chromosome aneuploidies (SCA) (XXY, X0, XYY, XXX)
- Y-chromosome microdeletions (AZFa, AZFb, AZFc)
Yourgene® Male Factor Infertility Range
The Yourgene® Male Factor Infertility Base assay is a multiplex assay containing 12 prescribed markers and primers to detect Y-chromosome microdeletions affecting the AZFa, AZFb and AZFc regions.
Enhanced microdeletion characterisation
The Yourgene Male Factor Infertility Base assay can be paired with the Yourgene Male Factor Infertility Plus assay, which adds 11 additional Y‑chromosome markers for enhanced microdeletion characterisation.
The Yourgene® Male Factor Infertility Base assay of products is available as CE-marked in vitro diagnostic products (IVD), is registered with Health Canada/TGA/SFDA, and is available as a Research Use Only (RUO) product. Yourgene® Male Factor Infertility Plus is available as a CE-marked in vitro diagnostic product (IVD).
Rapid Workflow. Faster Patient Results.
The Yourgene® Male Factor Infertility Base assay is easy to set up and involves minimal hands-on time. DNA extracted from whole blood is amplified using QF-PCR and analysed quantitatively on a capillary electrophoresis genetic analyser. Results review and interpretation is simple with no data transfer required.
- Simple set up – one tube per sample
- Rapid – minimum hands on time, just add DNA
- One step protocol – DNA extraction to PCR
- Reduced risk of sample mix-up
- Efficient – fewer consumables, reduced cost
- Validated for use on the ABI 3130 and 3500 Genetic Analysers
- Highly informative – multiplexed 5 dye chemistry
- No post-PCR manipulation
- One capillary per sample
- Cost effective – less instrument consumables
- GeneMarker™ and GeneMapper® software applications
- Simple data review and analysis
- Easy to use intuitive software
- Informative single page report
- No data transfer required
Complete Male Infertility Investigation
Mutations in the Cystic Fibrosis Transmembrane Receptor (CFTR) gene are associated with a significantly increased prevalence of infertility in males*.
The Yourgene® Male Factor Infertility assays can be combined with the Yourgene® Cystic Fibrosis screening range to provide a comprehensive genetic investigation for male infertility. This integrated approach enables detection of Y-chromosome microdeletions, sex chromosome aneuploidies, and CFTR variants, supporting a complete infertility diagnostic assessment.
*(98% of men with Cystic Fibrosis have fertility issues).
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